Micro RNA expression profiling in human hepatocellular carcinoma

Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma.

PURPOSE Hepatocellular carcinoma (HCC), a common cancer worldwide, has a dismal outcome partly due to the poor identification of early-stage HCC. Currently, one third of HCC patients present with low serum alpha-fetoprotein (AFP) levels, the only clinically available diagnostic marker for HCC. The aim of this study was to identify new diagnostic molecular markers for HCC, especially for individ...

Gene expression profiling analysis of hepatocellular carcinoma

BACKGROUND Primary hepatocellular carcinoma (HCC) is one of the most common malignancies in the world. However, the molecular pathogenesis of HCC is not well-understood, and the prognosis for patients with HCC remains very poor. METHODS To disclose detailed genetic mechanisms in hepatocellular carcinoma (HCC) with a view toward development of novel therapeutic targets, we analyzed expression ...

Hepatocellular Carcinoma in Sheep

Increased expression of human ribosomal phosphoprotein P0 messenger RNA in hepatocellular carcinoma and colon carcinoma.

To search for differentially expressed gene products in selected cancers of endodermal origin, cDNA libraries derived from mRNA in human hepatocellular carcinoma and adjacent grossly normal tissue were generated. From these parent libraries, subtracted cDNA libraries of tumor minus normal and normal minus tumor tissues were constructed. After screening these subtracted libraries by +/- hybridiz...

Enhanced RBM8A expression in human hepatocellular carcinoma

Objective: To investigate the expression level of RBM8A and its significance in HCC. Methods: RT-PCR method, immunohistochemistry and Western blot assay were performed to detect RBM8A expression in 105 cases of HCC tissues, adjacent tissues and 67 cases of normal liver tissues; The relationship between RBM8A expression and clinicopathological features of HCC was analyzed. Results: RT-PCR showed...